Lane, J.A., Howson, J., Donovan, J.L., Goepel, J.R., Dedman, D.J., Down, L., Turner, E.L., Neal, D.E. and Hamdy, F.C. (2007) Detection of prostate cancer in unselected young men: prospective cohort nested within a randomised controlled trial. BMJ, 335 (7630). pp. 1139-1143. ISSN 0959-8146
Objective: To investigate the feasibility of testing for prostate cancer and the prevalence and characteristics of the disease in unselected young men.
Design: Prospective cohort nested within a randomised controlled trial, with two years of follow-up.
Setting: Eight general practices in a UK city.
Participants: 1299 unselected men aged 45-49.
Intervention: Prostate biopsies for participants with a prostate specific antigen level of 1.5 ng/ml or more and the possibility of randomisation to three treatments for those with localised prostate cancer.
Main outcome measures: Uptake of testing for prostate specific antigen; positive predictive value of prostate specific antigen; and prevalence of prostate cancer, TNM disease stage, and histological grade (Gleason score 6-10). Results 442 of 1299 men agreed to be tested for prostate specific antigen (34%) and 54 (12%) had a raised level. The positive predictive value for prostate specific antigen was 21.3%. Ten cases of prostate cancer were detected (2.31/6) with eight having at least two positive results in biopsy cores and three showing perineural invasion. One tumour was of high volume (cT2c), Gleason score 7, with a positive result on digital rectal examination; nine tumours were cT1c, Gleason score 6, and eight had a negative result on digital rectal examination. Five of the nine eligible participants (55%) agreed to be randomised. No biochemical disease progression occurred in two years of follow-up.
Conclusions: Men younger than 50 will accept testing for prostate cancer but at a much tower rate than older men. Using an age based threshold of 1.5 ng/ml, the prevalence of prostate cancer was similar to that in older men (3.0 ng/ml threshold) and some cancers of potential clinical significance were found.
|Institution:||The University of Sheffield|
|Academic Units:||The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Medicine (Sheffield)|
|Depositing User:||Repository Officer|
|Date Deposited:||03 Nov 2008 19:15|
|Last Modified:||03 Nov 2008 19:15|