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Factors that influence health-related quality of life in Australian adults with Charcot-Marie-Tooth disease

Redmond, A.C., Burns, J. and Ouvrier, R.A. (2008) Factors that influence health-related quality of life in Australian adults with Charcot-Marie-Tooth disease. Neuromuscular Disorders, 18 (8). pp. 619-625. ISSN 0960-8966

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Abstract

Health-related, quality of life (HRQoL) is an important outcome in clinical trials of patients with Charcot–Marie–Tooth disease (CMT). In a cross-sectional survey of 295 Australian adults with CMT, HRQoL was measured using the Short Form-36 (SF-36) and predictors of reduced HRQoL were identified with a CMT-specific health status questionnaire. People with CMT demonstrated lower HRQoL scores than the general Australian population in all SF-36 dimensions. The disparity between people with CMT and normative data was greater for physical dimensions than for mental health dimensions. SF-36 scores were generally lower in older vs younger people, but not between men and women, or between CMT types. HRQoL in CMT was predicted strongly by lower limb weakness and to a lessor extent by leg cramps, suggesting clinical trials targeting weakness and cramps may improve HRQoL in patients with CMT.

Item Type: Article
Copyright, Publisher and Additional Information: © 2008 Elsevier B.V. This is an author produced version of a paper published in Neuromuscular Disorders. Uploaded in accordance with the publisher's self archiving policy.
Academic Units: The University of Leeds > Faculty of Medicine and Health (Leeds) > Institute of Molecular Medicine (LIMM) (Leeds) > Section of Musculoskeletal Disease (Leeds)
Depositing User: Sherpa Assistant
Date Deposited: 06 Nov 2008 09:19
Last Modified: 08 Feb 2013 17:05
Published Version: http://dx.doi.org/10.1016/j.nmd.2008.05.015
Status: Published
Publisher: Elsevier B.V.
Identification Number: 10.1016/j.nmd.2008.05.015
URI: http://eprints.whiterose.ac.uk/id/eprint/4808

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