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The burden of invasive pneumococcal disease and the potential for reduction by immunisation

Parsons, H. K. and Dockrell, D. H. (2002) The burden of invasive pneumococcal disease and the potential for reduction by immunisation. International journal of antimicrobial agents, 19 (2). pp. 85-93. ISSN 0924-8579

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Streptococcus pneumoniae causes invasive disease world-wide and in all age groups. The reported incidence varies geographically and is increased in certain population groups. The incidence is highest in children less than 2 years and is also increased in the elderly. Mortality remains substantial even in the developed world despite appropriate antimicrobial therapy. The emergence of penicillin-resistant pneumococci highlights the importance of immunisation as a means to prevent disease. This review discusses the burden of invasive pneumococcal disease, identifies high-risk patients and analyses evidence for vaccine efficacy and cost-effectiveness.

Item Type: Article
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Medicine (Sheffield)
Depositing User: Miss Anthea Tucker
Date Deposited: 29 Mar 2012 09:44
Last Modified: 29 Mar 2012 09:44
Published Version: http://dx.doi.org/10.1016/S0924-8579(01)00491-5
Status: Published
Publisher: Elsevier
Identification Number: 10.1016/S0924-8579(01)00491-5
Related URLs:
URI: http://eprints.whiterose.ac.uk/id/eprint/43822

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