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Toll-like receptors in health and disease: complex questions remain

Sabroe, I., Read, R. C., Whyte, M. K. B., Dockrell, D. H., Vogel, S. N. and Dower, S. K. (2003) Toll-like receptors in health and disease: complex questions remain. The Journal of Immunology, 171 (4). pp. 1630-1635. ISSN 0022-1767

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Until recently, the manner in which we respond to pathogens was obscure. It is now clear that a family of proteins, the Toll-like receptors (TLRs),3 contribute to the signal transduction induced by many pathogen-associated molecular patterns (PAMPs), and perhaps also to endogenous damage signals generated at sites of inflammation. Some TLRs act as central integrators of a wide variety of signals, responding to diverse agonists with an apparently common output, while other members of the family show (to date) considerable specificity with regard to their stimuli. However, many questions remain regarding the immunopharmacology of TLRs, their roles in innate immunity, and their manipulation by pathogens.

Item Type: Article
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Medicine (Sheffield)
Depositing User: Miss Anthea Tucker
Date Deposited: 29 Mar 2012 09:45
Last Modified: 29 Mar 2012 09:45
Published Version: http://www.jimmunol.org/content/171/4/1630.long
Status: Published
Publisher: American Association of Immunologists
Related URLs:
URI: http://eprints.whiterose.ac.uk/id/eprint/43819

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