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The multiple roles of Fas ligand in the pathogenesis of infectious diseases

Dockrell, D. H. (2003) The multiple roles of Fas ligand in the pathogenesis of infectious diseases. Clinical Microbiology And Infection, 9 (8). pp. 766-779. ISSN 1198-743X

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Abstract

Fas ligand (FasL) is a type II transmembrane protein that plays a critical role in immune homeostasis by binding to its receptor Fas (CD95) and inducing apoptosis. Fas/FasL dysregulation contributes to infectious disease pathogenesis. Microorganisms may inhibit Fas signal transduction to prolong intracellular survival and prevent killing by immune effector cells. FasL may be upregulated in directly infected cells to enhance killing of responding immune cells and facilitate immune evasion. The host response to infection may aim to induce apoptosis in directly infected cells, but immune cells that target directly infected cells can induce Fas-mediated apoptosis of uninfected bystander cells. FasL also contributes to the generation and regulation of the inflammatory response in infection. The multiple roles of FasL in infectious disease pathogenesis are discussed in the context of viral, bacterial and parasitic infections.

Item Type: Article
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Medicine (Sheffield)
Depositing User: Miss Anthea Tucker
Date Deposited: 29 Mar 2012 09:46
Last Modified: 29 Mar 2012 09:46
Published Version: http://dx.doi.org/10.1046/j.1469-0691.2003.00669.x
Status: Published
Publisher: Blackwell Publishing
Identification Number: 10.1046/j.1469-0691.2003.00669.x
Related URLs:
URI: http://eprints.whiterose.ac.uk/id/eprint/43816

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