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Inhibition of macrophage apoptosis by Neisseria meningitidis requires nitric oxide detoxification mechanisms

Tunbridge, A. J., Stevanin, T. M., Lee, M., Marriott, H. M., Moir, J. W. B., Read, R. C. and Dockrell, D. H. (2006) Inhibition of macrophage apoptosis by Neisseria meningitidis requires nitric oxide detoxification mechanisms. Infection and immunity, 74 (1). pp. 729-733. ISSN 0019-9567

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Abstract

Host-driven macrophage apoptosis contributes to innate immunity during bacterial infection. Neisseria meningitidis inhibits apoptosis in a variety of cells, but its impact on macrophage apoptosis is unknown. We demonstrate that N. meningitidis prevents macrophage apoptosis via genes encoding nitric oxide detoxification and a porin, PorB.

Item Type: Article
Academic Units: The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Medicine (Sheffield)
Depositing User: Miss Anthea Tucker
Date Deposited: 29 Mar 2012 09:48
Last Modified: 29 Mar 2012 09:48
Published Version: http://dx.doi.org/10.1128/​IAI.74.1.729-733.2006
Status: Published
Publisher: American Society for Microbiology
Identification Number: 10.1128/​IAI.74.1.729-733.2006
Related URLs:
URI: http://eprints.whiterose.ac.uk/id/eprint/43812

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