Bianchi, S. M., Dockrell, D. H., Renshaw, S. A., Sabroe, I. and Whyte, M. K. B. (2006) Granulocyte apoptosis in the pathogenesis and resolution of lung disease. Clinical science, 110 (3). pp. 293-304. ISSN 0143-5221
Full text not available from this repository.Abstract
Apoptosis, programmed cell death, of neutrophil and eosinophil granulocytes is a potential control point in the physiological resolution of innate immune responses. There is also increasing evidence that cellular processes of apoptosis can be dysregulated by pathogens as a mechanism of immune evasion and that delayed apoptosis, resulting in prolonged inflammatory cell survival, is important in persistence of tissue inflammation. The identification of cell-type specific pathways to apoptosis may allow the design of novel anti-inflammatory therapies or agents to augment the innate immune responses to infection. This review will explore the physiological roles of granulocyte apoptosis and their importance in infectious and non-infectious lung disease.
| Item Type: | Article |
|---|---|
| Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Medicine (Sheffield) |
| Depositing User: | Miss Anthea Tucker |
| Date Deposited: | 29 Mar 2012 09:49 |
| Last Modified: | 29 Mar 2012 09:49 |
| Published Version: | http://www.clinsci.org/cs/110/0293/cs1100293.htm |
| Status: | Published |
| Publisher: | Portland Press |
| Related URLs: | |
| URI: | http://eprints.whiterose.ac.uk/id/eprint/43811 |
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