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Granulocyte apoptosis in the pathogenesis and resolution of lung disease

Bianchi, S. M., Dockrell, D. H., Renshaw, S. A., Sabroe, I. and Whyte, M. K. B. (2006) Granulocyte apoptosis in the pathogenesis and resolution of lung disease. Clinical science, 110 (3). pp. 293-304. ISSN 0143-5221

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Abstract

Apoptosis, programmed cell death, of neutrophil and eosinophil granulocytes is a potential control point in the physiological resolution of innate immune responses. There is also increasing evidence that cellular processes of apoptosis can be dysregulated by pathogens as a mechanism of immune evasion and that delayed apoptosis, resulting in prolonged inflammatory cell survival, is important in persistence of tissue inflammation. The identification of cell-type specific pathways to apoptosis may allow the design of novel anti-inflammatory therapies or agents to augment the innate immune responses to infection. This review will explore the physiological roles of granulocyte apoptosis and their importance in infectious and non-infectious lung disease.

Item Type: Article
Academic Units: The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Medicine (Sheffield)
Depositing User: Miss Anthea Tucker
Date Deposited: 29 Mar 2012 09:49
Last Modified: 29 Mar 2012 09:49
Published Version: http://www.clinsci.org/cs/110/0293/cs1100293.htm
Status: Published
Publisher: Portland Press
Related URLs:
URI: http://eprints.whiterose.ac.uk/id/eprint/43811

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