Marriott, H. M., Hellewell, P. G., Whyte, M. K. B. and Dockrell, D. H. (2007) Contrasting roles for reactive oxygen species and nitric oxide in the innate response to pulmonary infection with Streptococcus pneumoniae. Vaccine, 25 (13). pp. 2485-2490. ISSN 0264-410X
Full text not available from this repository.Abstract
The pulmonary innate response to low-dose bacterial challenge requires functioning alveolar macrophages (AM) but also subsequent macrophage apoptosis. To address the role of reactive oxygen species (ROS) and nitric oxide (NO) in AM apoptosis, sub-clinical Streptococcus pneumoniae infection was established in gp91(phox-/-) and inducible NO synthase deficient (iNOS(-/-)) mice. Both AM apoptosis and the number of macrophages containing apoptotic bodies are reduced in iNOS(-/-) as compared to control or gp91(phox-/-) mice. iNOS(-/-) mice recruit neutrophils and generate TNF-alpha to compensate for impaired AM competence but ROS deficiency has no apparent effect on AM function in this model.
| Item Type: | Article |
|---|---|
| Keywords: | Macrophages; Apoptosis; Pneumococci; Mice; Nitric oxide |
| Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Medicine (Sheffield) |
| Depositing User: | Miss Anthea Tucker |
| Date Deposited: | 29 Mar 2012 09:50 |
| Last Modified: | 29 Mar 2012 09:50 |
| Published Version: | http://dx.doi.org/10.1016/j.vaccine.2006.09.024 |
| Status: | Published |
| Publisher: | Elsevier |
| Identification Number: | 10.1016/j.vaccine.2006.09.024 |
| Related URLs: | |
| URI: | http://eprints.whiterose.ac.uk/id/eprint/43808 |
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