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Contrasting roles for reactive oxygen species and nitric oxide in the innate response to pulmonary infection with Streptococcus pneumoniae

Marriott, H. M., Hellewell, P. G., Whyte, M. K. B. and Dockrell, D. H. (2007) Contrasting roles for reactive oxygen species and nitric oxide in the innate response to pulmonary infection with Streptococcus pneumoniae. Vaccine, 25 (13). pp. 2485-2490. ISSN 0264-410X

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Abstract

The pulmonary innate response to low-dose bacterial challenge requires functioning alveolar macrophages (AM) but also subsequent macrophage apoptosis. To address the role of reactive oxygen species (ROS) and nitric oxide (NO) in AM apoptosis, sub-clinical Streptococcus pneumoniae infection was established in gp91(phox-/-) and inducible NO synthase deficient (iNOS(-/-)) mice. Both AM apoptosis and the number of macrophages containing apoptotic bodies are reduced in iNOS(-/-) as compared to control or gp91(phox-/-) mice. iNOS(-/-) mice recruit neutrophils and generate TNF-alpha to compensate for impaired AM competence but ROS deficiency has no apparent effect on AM function in this model.

Item Type: Article
Keywords: Macrophages; Apoptosis; Pneumococci; Mice; Nitric oxide
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Medicine (Sheffield)
Depositing User: Miss Anthea Tucker
Date Deposited: 29 Mar 2012 09:50
Last Modified: 29 Mar 2012 09:50
Published Version: http://dx.doi.org/10.1016/j.vaccine.2006.09.024
Status: Published
Publisher: Elsevier
Identification Number: 10.1016/j.vaccine.2006.09.024
Related URLs:
URI: http://eprints.whiterose.ac.uk/id/eprint/43808

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