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Reactive oxygen species regulate neutrophil recruitment and survival in pneumococcal pneumonia

Marriott, H. M., Jackson, L. E., Wilkinson, T. S., Simpson, A. J., Mitchell, T. J., Buttle, D. J., Cross, S. S., Ince, P. G., Hellewell, P. G., Whyte, M. K. B. and Dockrell, D. H. (2008) Reactive oxygen species regulate neutrophil recruitment and survival in pneumococcal pneumonia. American journal of respiratory and critical care medicine, 177 (8). pp. 887-895. ISSN 1535-4970

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Abstract

During pneumococcal pneumonia, NADPH oxidase-derived reactive oxygen species are redundant for host defense but limit neutrophil recruitment and survival. Decreased NADPH oxidase-dependent reactive oxygen species production is well tolerated and improves disease outcome during pneumococcal pneumonia by removing neutrophils from the tight constraints of reactive oxygen species-mediated regulation.

Item Type: Article
Academic Units: The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Medicine (Sheffield) > Department of Infection & Immunity
Depositing User: Miss Anthea Tucker
Date Deposited: 29 Mar 2012 09:52
Last Modified: 29 Mar 2012 09:52
Published Version: http://dx.doi.org/10.1164/rccm.200707-990OC
Status: Published
Publisher: American Thoracic Society
Identification Number: 10.1164/rccm.200707-990OC
Related URLs:
URI: http://eprints.whiterose.ac.uk/id/eprint/43801

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