Grenha, R, Levdikov, V M, Fogg, M J et al. (4 more authors) (2005) Structure of purine nucleoside phosphorylase (DeoD) from Bacillus anthracis. Acta Crystallographica Section F: Structural Biology and Crystallization Communications. pp. 459-462. ISSN 1744-3091
Protein structures from the causative agent of anthrax (Bacillus anthracis) are being determined as part of a structural genomics programme. Amongst initial candidates for crystallographic analysis are enzymes involved in nucleotide biosynthesis, since these are recognized as potential targets in antibacterial therapy. Purine nucleoside phosphorylase is a key enzyme in the purine-salvage pathway. The crystal structure of purine nucleoside phosphorylase (DeoD) from B. anthracis has been solved by molecular replacement at 2.24 Å resolution and refined to an R factor of 18.4%. This is the first report of a DeoD structure from a Gram-positive bacterium.
|Copyright, Publisher and Additional Information:||Copyright © 2005 International Union of Crystallography - http://www.iucr.org/cgi-bin/paper?gx5050|
|Institution:||The University of York|
|Academic Units:||The University of York > Chemistry (York)|
|Depositing User:||Repository Officer|
|Date Deposited:||11 May 2005|
|Last Modified:||01 Jan 2017 05:31|