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The role of TLRs in neutrophil activation

Prince, L.R., Whyte, M.K., Sabroe, I. and Parker, L.C. (2011) The role of TLRs in neutrophil activation. Current Opinion in Pharmacology, 11 (4). pp. 397-403. ISSN 1471-4892

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Neutrophils are key innate immune effector cells that are rapidly recruited to sites of infection and inflammation to provide early defence against invading microorganisms. This function is facilitated by the expression of Toll-like receptor (TLR) family members by neutrophils, allowing the recognition of an extensive repertoire of pathogen-associated molecular patterns (PAMPs) and thus triggering the response to invading pathogens. TLR activation leads to important cellular processes including reactive oxygen species (ROS) generation, cytokine production and increased survival, all of which can contribute to the pathogenesis of chronic inflammation when signalling becomes dysregulated. In turn, inflammation and tissue injury results in the release of endogenous TLR ligands, known as damage-associated molecular patterns (DAMPs), which are a rapidly growing class of potent inflammatory stimuli. DAMPs act in an autocrine manner, alerting the host of damage, but can also amplify inflammation leading to further tissue damage. This review highlights recent literature on neutrophil TLR function and regulation during disease, and provides an overview of the recently emerging area of neutrophil responses to DAMPs.

Item Type: Article
Copyright, Publisher and Additional Information: © 2011 Elsevier. This is an author produced version of a paper subsequently published in Current Opinion in Pharmacology. Uploaded in accordance with the publisher's self-archiving policy.
Keywords: Toll-Like Receptors; Pattern-Recognition Receptors; Obstructive Pulmonary-Disease; Bronchoalveolar Lavage Fluid; Respiratory Syncytial Virus; Induced Lung Injury; Gene-Expression; IRAK-4 Deficiency; Phosphatidylinositol 3-Kinase; Granulocyte Apoptosis
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Medicine (Sheffield) > Department of Infection & Immunity
Depositing User: Miss Anthea Tucker
Date Deposited: 03 Oct 2011 11:03
Last Modified: 03 Oct 2011 11:03
Published Version: http://dx.doi.org/10.1016/j.coph.2011.06.007
Status: Published
Publisher: Elsevier
Refereed: Yes
Identification Number: 10.1016/j.coph.2011.06.007
URI: http://eprints.whiterose.ac.uk/id/eprint/43291

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