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Localisation of the gene for familial adenomatous polyposis on chromosome 5

Rider, SH, Bodmer, WF, Bailey, CJ, Bodmer, J, Bussey, HJR, Ellis, A, Gorman, P, Lucibello, FC, Murday, VA, Scambler, P, Sheer, D, Solomon, E and Spurr, NK (1987) Localisation of the gene for familial adenomatous polyposis on chromosome 5. Nature, 328. 614 - 616 . ISSN 0028-0836

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Abstract

Colorectal cancer is the second most common cancer in the United Kingdom and other developed countries in the West. Although it is usually not familial, there is a rare dominantly inherited susceptibility to colon cancer, familial adenomatous polyposis (FAP; also often previously called familial polyposis coli). During adolescence affected individuals develop from a few hundred to over a thousand adenomatous polyps in their large bowel. These are sufficiently likely to give rise to adenocarcinomas to make prophylactic removal of the colon usual in diagnosed FAP individuals. Adenomas may occur elsewhere in the gastrointestinal tract and the condition is often associated with other extracolonic lesions, such as epidermoid cysts, jaw osteomata and fibrous desmoid tumours1–4. Adenomata have been suggested to be precancerous states for most colorectal tumours5,6. Knudson7 has suggested that the mutation for a dominantly inherited cancer susceptibility may be the first step in a recessive change in the tumour cells, and that the same gene may be involved in both familial and non-familial cases of a given tumour. Following up a case report of an interstitial deletion of chromosome 5 in a mentally retarded individual with multiple developmental abnormalities and FAP8, we have now shown that the FAP gene is on chromosome 5, most probably near bands 5q21–q22.

Item Type: Article
Institution: The University of Leeds
Academic Units: The University of Leeds > Faculty of Medicine and Health (Leeds) > Institute of Health Sciences (Leeds) > Academic Unit of Psychiatry and Behavioural Sciences (Leeds)
Depositing User: Symplectic Publications
Date Deposited: 13 Jun 2011 11:41
Last Modified: 08 Feb 2013 17:32
Status: Published
Publisher: Nature Publishing Group
URI: http://eprints.whiterose.ac.uk/id/eprint/43038

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