Effective caspase inhibition blocks neutrophil apoptosis and reveals Mcl-1 as both a regulator and a target of neutrophil caspase activation

Wardle, D.J., Burgon, J., Sabroe, I., Bingle, C.D., Whyte, M.K.B. and Renshaw, S.A. (2011) Effective caspase inhibition blocks neutrophil apoptosis and reveals Mcl-1 as both a regulator and a target of neutrophil caspase activation. Plos One, 6 (1). Art no.e15768. ISSN 1932-6203

Abstract

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Authors/Creators:
  • Wardle, D.J.
  • Burgon, J.
  • Sabroe, I.
  • Bingle, C.D.
  • Whyte, M.K.B.
  • Renshaw, S.A.
Copyright, Publisher and Additional Information: © 2011 Wardle et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Keywords: Cell-Survival; Expression; Resolution; Cleavage; Inflammation; Receptor; Hypoxia; Death; Lipopolysaccharide; Granulocytes
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Medicine (Sheffield) > Department of Infection & Immunity
The University of Sheffield > Faculty of Science (Sheffield) > School of Biological Sciences (Sheffield) > Department of Biomedical Science (Sheffield) > Centre for Developmental Genetics (Sheffield)
The University of Sheffield > University of Sheffield Research Centres and Institutes > Centre for Developmental Genetics (Sheffield)
Depositing User: Miss Anthea Tucker
Date Deposited: 07 Mar 2011 16:13
Last Modified: 10 Jun 2014 01:09
Published Version: http://dx.doi.org/10.1371/journal.pone.0015768
Status: Published
Publisher: Public Library Science
Refereed: Yes
Identification Number: 10.1371/journal.pone.0015768

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Filename: Renshaw_Effective.pdf

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