Walker, D.C., Southgate, J., Hill, G. et al. (5 more authors) (2004) The Epitheliome: agent-based modelling of the social behaviour of cells. BioSystems, 76 (1-3). pp. 89-100. ISSN 0303-2647
Abstract
We have developed a new computational modelling paradigm for predicting the emergent behaviour resulting from the interaction of cells in epithelial tissue. As proof-of-concept, an agent-based model, in which there is a one-to-one correspondence between biological cells and software agents, has been coupled to a simple physical model. Behaviour of the computational model is compared with the growth characteristics of epithelial cells in monolayer culture, using growth media with low and physiological calcium concentrations. Results show a qualitative fit between the growth characteristics produced by the simulation and the in vitro cell models.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | Copyright © 2004 Elsevier Ireland Ltd. All rights reserved. Further information at http://www.dcs.shef.ac.uk/~rod/Integrative_Systems_Biology.html |
Keywords: | Computational modelling, software agent, epithelium, urothelium, cell culture, calcium |
Dates: |
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Institution: | The University of Sheffield, The University of York |
Academic Units: | The University of Sheffield > Faculty of Engineering (Sheffield) > Department of Materials Science and Engineering (Sheffield) The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > The Medical School (Sheffield) > Clinical Sciences Division South (Sheffield) > Department of Medical Physics and Clinical Engineering (Sheffield) The University of York > Faculty of Sciences (York) > Biology (York) The University of Sheffield > Faculty of Engineering (Sheffield) > Department of Computer Science (Sheffield) |
Depositing User: | Rod Smallwood |
Date Deposited: | 12 Feb 2007 |
Last Modified: | 04 Jun 2014 16:21 |
Published Version: | http://www.elsevier.com/wps/find/journaldescriptio... |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1016/j.biosystems.2004.05.025 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:421 |