Smallwood, R.H. [r.smallwood@shef.ac.uk], Holcombe, W.M.L. and Walker, D.C. (2004) Development and validation of computational models of cellular interaction. Journal of Molecular Histology, 35 (7). pp. 659-665. ISSN 1567-2379
Abstract
In this paper we take the view that computational models of biological systems should satisfy two conditions – they should be able to predict function at a systems biology level, and robust techniques of validation against biological models must be available. A modelling paradigm for developing a predictive computational model of cellular interaction is described, and methods of providing robust validation against biological models are explored, followed by a consideration of software issues.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2004 Kluwer Academic Publishers. Further information at http://www.dcs.shef.ac.uk/~rod/Integrative_Systems_Biology.html |
Keywords: | Computational biology, modelling, individual-based modelling, validation, prediction |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Engineering (Sheffield) > Department of Computer Science (Sheffield) |
Depositing User: | Rod Smallwood |
Date Deposited: | 28 Apr 2005 |
Last Modified: | 06 Jun 2014 00:39 |
Published Version: | http://www.springeronline.com/sgw/cda/frontpage/0,... |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1007/s10735-004-2660-1 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:420 |