Economics of tandem mass spectrometry screening of neonatal inherited disorders

Pandor, A., Eastham, J., Chilcott, J., Paisley, S. and Beverley, C. (2006) Economics of tandem mass spectrometry screening of neonatal inherited disorders. International Journal of Technology Assessment in Health Care, 22 (3). pp. 321-326. ISSN 1471-6348

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Abstract

Objectives: The aim of this study was to evaluate the cost-effectiveness of neonatal screening for phenylketonuria (PKU) and medium-chain acyl-coA dehydrogenase (MCAD) deficiency using tandem mass spectrometry (tandem MS).

Methods: A systematic review of clinical efficacy evidence and cost-effectiveness modeling of screening in newborn infants within a UK National Health Service perspective was performed. Marginal costs, life-years gained, and cost-effectiveness acceptability curves are presented.

Results: Substituting the use of tandem MS for existing technologies for the screening of PKU increases costs with no increase in health outcomes. However, the addition of screening for MCAD deficiency as part of a neonatal screening program for PKU using tandem MS, with an operational range of 50,000 to 60,000 specimens per system per year, would result in a mean incremental cost of −£17,298 (−£129,174, £66,434) for each cohort of 100,000 neonates screened. This cost saving is associated with a mean incremental gain of 57.3 (28.0, 91.4) life-years.

Conclusions: Cost-effectiveness analysis using economic modeling indicates that substituting the use of tandem MS for existing technologies for the screening of PKU alone is not economically justified. However, the addition of screening for MCAD deficiency as part of a neonatal screening program for PKU using tandem MS would be economically attractive.

Item Type:	Article
Copyright, Publisher and Additional Information:	Copyright © 2006 Cambridge University Press. Reproduced in accordance with the publisher's self-archiving policy.
Keywords:	Spectrum analysis, mass, infant, newborn, neonatal screening, phenylketonurias, metabolism, inborn errors, medium chain acyl co-A dehydrogenase deficiency, costs and cost analysis
Academic Units:	The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Health and Related Research (Sheffield)
Depositing User:	Repository Officer
Date Deposited:	24 Jan 2008 19:27
Last Modified:	08 Feb 2013 16:55
Published Version:	http://dx.doi.org/10.1017/S026646230605121X
Status:	Published
Publisher:	Cambridge University Press
Refereed:	Yes
Identification Number:	doi: 10.1017/S026646230605121X
URI:	http://eprints.whiterose.ac.uk/id/eprint/3503

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