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Pot, atom and step economic (PASE) synthesis of highly functionalized piperidines: a five-component condensation

Clarke, Paul A., Zaytzev, Andrey V. and Whitwood, Adrian C. (2007) Pot, atom and step economic (PASE) synthesis of highly functionalized piperidines: a five-component condensation. Tetrahedron Letters. pp. 5209-5212. ISSN 0040-4039

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Abstract

The diastereoselective pot, atom and step economic (PASE) synthesis of highly functionalized piperidines has been realized. The procedure simply involves mixing methyl acetoacetate, 2 equiv of aldehyde and 2 equiv of aniline together in the presence of InCl3. In most cases the piperidine precipitates out of solution. (c) 2007 Elsevier Ltd. All rights reserved.

Item Type: Article
Keywords: piperidines, PASE, one-pot, multi-component, MAITLAND-JAPP REACTION, IDEAL SYNTHESIS, TETRAHYDROPYRAN-4-ONES, CONSTRUCTION, AMINES, WATER
Institution: The University of York
Academic Units: The University of York > Chemistry (York)
Depositing User: Ms Diana Hilmer
Date Deposited: 15 Oct 2007 16:46
Last Modified: 14 Oct 2014 09:26
Published Version: http://dx.doi.org/10.1016/j.tetlet.2007.05.141
Status: Published
Refereed: Yes
Related URLs:
URI: http://eprints.whiterose.ac.uk/id/eprint/3384

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