Clarke, Paul A. orcid.org/0000-0003-3952-359X, Zaytzev, Andrey V. and Whitwood, Adrian C. (2007) Pot, atom and step economic (PASE) synthesis of highly functionalized piperidines: a five-component condensation. Tetrahedron Letters. pp. 5209-5212. ISSN 0040-4039
Abstract
The diastereoselective pot, atom and step economic (PASE) synthesis of highly functionalized piperidines has been realized. The procedure simply involves mixing methyl acetoacetate, 2 equiv of aldehyde and 2 equiv of aniline together in the presence of InCl3. In most cases the piperidine precipitates out of solution. (c) 2007 Elsevier Ltd. All rights reserved.
Metadata
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Keywords: | piperidines, PASE, one-pot, multi-component, MAITLAND-JAPP REACTION, IDEAL SYNTHESIS, TETRAHYDROPYRAN-4-ONES, CONSTRUCTION, AMINES, WATER | ||||
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Institution: | The University of York | ||||
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) | ||||
Funding Information: |
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Depositing User: | Ms Diana Hilmer | ||||
Date Deposited: | 15 Oct 2007 16:46 | ||||
Last Modified: | 06 Dec 2023 10:39 | ||||
Published Version: | https://doi.org/10.1016/j.tetlet.2007.05.141 | ||||
Status: | Published | ||||
Refereed: | Yes | ||||
Identification Number: | https://doi.org/10.1016/j.tetlet.2007.05.141 | ||||
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