Parameters of the attenuated schistosome vaccine evaluated in the olive baboon

Kariuki, T.M., Farah, I.O., Yole, D.S., Mwenda, J.M., Van Dam, G.J., Deelder, A.M., Coulson, P.S. and Wilson, R.A. (2004) Parameters of the attenuated schistosome vaccine evaluated in the olive baboon. Infection and Immunity. pp. 5526-5529. ISSN 1098-5522

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Abstract

Five exposures of baboons to the attenuated schistosome vaccine gave greater protection than three exposures, but this attenuation was not sustained when challenge was delayed. Within the scope of the data collected, fecal egg counts and circulating antigen levels did not accurately predict the observed worm burdens. Levels of immunoglobulin G at challenge correlated best with protection, but there was little evidence of a recall response.

Item Type:	Article
Copyright, Publisher and Additional Information:	Copyright © 2004, American Society for Microbiology
Keywords:	IRRADIATED CERCARIA VACCINE, CIRCULATING ANODIC ANTIGEN, PAPIO-ANUBIS, MONOCLONAL-ANTIBODIES, PROTECTIVE IMMUNITY, MANSONI, RESPONSES
Academic Units:	The University of York > Biology (York)
Depositing User:	Sherpa Assistant
Date Deposited:	04 Mar 2005
Last Modified:	19 Feb 2013 11:52
Published Version:	http://dx.doi.org/10.1128/IAI.72.9.5526-5529.2004
Status:	Published
Refereed:	Yes
Related URLs:	http://iai.asm.org/
URI:	http://eprints.whiterose.ac.uk/id/eprint/331

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