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Hormone replacement therapy and prevention of vertebral fractures: a meta-analysis of randomised trials

Torgerson, David J. and Bell-Syer, Sally E.M. (2001) Hormone replacement therapy and prevention of vertebral fractures: a meta-analysis of randomised trials. BMC Musculoskeletal Disorders. ISSN 1471-2474

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Abstract

BACKGROUND: Hormone replacement therapy (HRT) is often seen as the treatment of choice for preventing fractures in women. We undertook a recent meta-analysis of randomised trials which suggested that HRT reduced non-vertebral fractures by 30%. In this analysis we extend that analysis to vertebral fractures. METHODS: We searched the main electronic databases until the end of August 2001. We sought all randomised controlled trials (RCTs) of HRT where women had been randomised to at least 12 months of HRT or to no HRT. RESULTS: We found 13 RCTs. Overall there was a 33% reduction in vertebral factures (95% confidence interval (CI) 45% to 98%). CONCLUSIONS: This review and meta-analysis showed a significant reduction in vertebral fractures associated with HRT use.

Item Type: Article
Copyright, Publisher and Additional Information: © 2001 Torgerson and Bell-Syer; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.
Academic Units: The University of York > Health Sciences (York)
Depositing User: Repository Officer
Date Deposited: 30 Jul 2004
Last Modified: 17 Oct 2013 14:34
Published Version: http://dx.doi.org/10.1186/1471-2474-2-7
Status: Published
Refereed: Yes
Related URLs:
URI: http://eprints.whiterose.ac.uk/id/eprint/32

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