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Staphylococcal peptidoglycans induce arthritis

Liu, Zai-Qing, Deng, Guo-Min, Foster, Simon and Tarkowski, Andrej (2001) Staphylococcal peptidoglycans induce arthritis. Arthritis Research and Therapy, 3 (6). pp. 375-380. ISSN 1478-6354


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Staphylococcus aureus is one of the most important pathogens in septic arthritis. To analyse the arthritogenic properties of staphylococcal peptidoglycan (PGN), highly purified PGN from S. aureus was intra-articularly injected into murine joints. The results demonstrate that PGN will trigger arthritis in a dose-dependent manner. A single injection of this compound leads to massive infiltration of predominantly macrophages and polymorphonuclear cells with occasional signs of cartilage and/or bone destruction, lasting for at least 14 days. Further studies showed that this condition is mediated by the combined impact of acquired and innate immune systems. Our results indicate that PGN exerts a central role in joint inflammation triggered by S. aureus.

Item Type: Article
Copyright, Publisher and Additional Information: © 2001 Liu et al, licensee BioMed Central Ltd
Keywords: arthritis, peptidoglycan, Staphylococcus aureus
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Science (Sheffield) > School of Biological Sciences (Sheffield) > Department of Molecular Biology and Biotechnology (Sheffield)
Depositing User: Repository Officer
Date Deposited: 19 Jul 2004
Last Modified: 05 Jun 2014 23:55
Published Version: http://arthritis-research.com/content/3/6/375
Status: Published
Refereed: Yes
Identification Number: 10.1186/ar330
URI: http://eprints.whiterose.ac.uk/id/eprint/21

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