Liu, Zai-Qing, Deng, Guo-Min, Foster, Simon et al. (1 more author) (2001) Staphylococcal peptidoglycans induce arthritis. Arthritis Research and Therapy, 3 (6). pp. 375-380. ISSN 1478-6354
Abstract
Staphylococcus aureus is one of the most important pathogens in septic arthritis. To analyse the arthritogenic properties of staphylococcal peptidoglycan (PGN), highly purified PGN from S. aureus was intra-articularly injected into murine joints. The results demonstrate that PGN will trigger arthritis in a dose-dependent manner. A single injection of this compound leads to massive infiltration of predominantly macrophages and polymorphonuclear cells with occasional signs of cartilage and/or bone destruction, lasting for at least 14 days. Further studies showed that this condition is mediated by the combined impact of acquired and innate immune systems. Our results indicate that PGN exerts a central role in joint inflammation triggered by S. aureus.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2001 Liu et al, licensee BioMed Central Ltd |
Keywords: | arthritis, peptidoglycan, Staphylococcus aureus |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Science (Sheffield) > School of Biosciences (Sheffield) > Department of Molecular Biology and Biotechnology (Sheffield) |
Depositing User: | Repository Officer |
Date Deposited: | 19 Jul 2004 |
Last Modified: | 05 Jun 2014 23:55 |
Published Version: | http://arthritis-research.com/content/3/6/375 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1186/ar330 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:21 |