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Lateral phase separation in mixtures of lipids and cholesterol

Komura, S., Shirotori, H., Olmsted, P.D. and Andelman, D. (2004) Lateral phase separation in mixtures of lipids and cholesterol. Europhysics Letters, 67 (2). pp. 321-327. ISSN 1286-4854

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In an effort to understand "rafts" in biological membranes, we propose phenomenological models for saturated and unsaturated lipid mixtures, and lipid-cholesterol mixtures. We consider simple couplings between the local composition and internal membrane structure, and their influence on transitions between liquid and gel membrane phases. Assuming that the gel transition temperature of the saturated lipid is shifted by the presence of the unsaturated lipid, and that cholesterol acts as an external field on the chain melting transition, a variety of phase diagrams are obtained. The phase diagrams for binary mixtures of saturated/unsaturated lipids and lipid/cholesterol are in semi-quantitative agreement with the experiments. Our results also apply to regions in the ternary phase diagram of lipid/lipid/cholesterol systems.

Item Type: Article
Copyright, Publisher and Additional Information: © 2004 EDP Sciences. Reproduced in accordance with the publisher's self-archiving policy.
Institution: The University of Leeds
Academic Units: The University of Leeds > Faculty of Maths and Physical Sciences (Leeds) > School of Physics and Astronomy (Leeds)
The University of Leeds > University of Leeds Research Centres and Institutes > Interdisciplinary Research Centre in Polymer Science and Technology (Leeds)
Depositing User: Repository Officer
Date Deposited: 08 Feb 2007
Last Modified: 06 Jun 2014 06:43
Published Version: http://dx.doi.org/10.1209/epl/i2004-10057-1
Status: Published
Publisher: EDP Sciences
Refereed: Yes
Identification Number: 10.1209/epl/i2004-10057-1
URI: http://eprints.whiterose.ac.uk/id/eprint/1956

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