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Enantioselective synthesis of non-proteinogenic 2-arylallyl-α-amino acids via Pd/In catalytic cascades

Grigg, R., McCaffrey, S., Sridharan, V., Fishwick, C.W.G., Kilner, C., Korn, S., Bailey, K. and Blacker, J. (2006) Enantioselective synthesis of non-proteinogenic 2-arylallyl-α-amino acids via Pd/In catalytic cascades. Tetrahedron, 62 (52). pp. 12159-12171. ISSN 0040-4020

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Abstract

An efficient synthesis of both R- and S-enantiomers of 2-arylallyl-α-amino acids via a diastereoselective Pd/In mediated catalytic allylation of chiral N-sulfinyl-α-imino esters is described. The potential for further enhancement of molecular complexity and creating contiguous chiral centres by interfacing these processes with catalytic cyclisation–anion capture methodology is demonstrated.

Item Type: Article
Copyright, Publisher and Additional Information: Copyright © 2006 Elsevier Ltd. This is an author produced version of a paper published in Tetrahedron.
Institution: The University of Leeds
Academic Units: The University of Leeds > Faculty of Maths and Physical Sciences (Leeds) > School of Chemistry (Leeds)
Depositing User: Repository Officer
Date Deposited: 05 Feb 2007
Last Modified: 08 Feb 2013 17:03
Published Version: http://dx.doi.org/10.1016/j.tet.2006.09.098
Status: Published
Publisher: Elsevier
Refereed: Yes
Identification Number: 10.1016/j.tet.2006.09.098
URI: http://eprints.whiterose.ac.uk/id/eprint/1939

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