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Colorectal Hepatic Metastases: Detection with SPIO-enhanced Breath-hold MR Imaging-Comparison of Optimized Sequences

Ward, J., Guthrie, J.A., Wilson, D., Arnold, P., Lodge, J.P., Toogood, G.J., Wyatt, J.I. and Robinson, P.J. (2003) Colorectal Hepatic Metastases: Detection with SPIO-enhanced Breath-hold MR Imaging-Comparison of Optimized Sequences. Radiology, 228 (3). pp. 709-718. ISSN 1527-1315


PURPOSE: To compare the accuracy of four breath-hold magnetic resonance (MR) imaging sequences to establish the most effective superparamagnetic iron oxide (SPIO)–enhanced sequence for detection of colorectal hepatic metastases.

MATERIALS AND METHODS: Thirty-one patients with colorectal hepatic metastases underwent T1-weighted gradient-echo (GRE) and T2-weighted fast spin-echo (FSE) MR imaging before and after SPIO enhancement. Four sequences were optimized for lesion detection: T2-weighted FSE, multiecho data image combination (MEDIC), T2-weighted GRE with an 11-msec echo time (TE), and T2-weighted GRE with a 15-msec TE. Images were reviewed independently by three blinded observers. The accuracy of each sequence was measured by using alternative free-response receiver operating characteristic analysis. All results were correlated with findings at surgery, intraoperative ultrasonography, or histopathologic examination. Differences between the mean results of the three observers were measured by using the Student t-test.

RESULTS: Postcontrast T2-weighted GRE sequences were the most accurate and were significantly superior to postcontrast T2-weighted FSE and unenhanced sequences alone (p<.05). For all lesions that were malignant or smaller than 1 cm, respectively, mean accuracies of postcontrast sequences were 0.082 and 0.64 for T2-weighted FSE, 0.90 and 0.78 for MEDIC, 0.92 and 0.80 for GRE with an 11-msec TE, 0.93 and 0.82 for GRE with a 15-msec TE, and 0.81 and 0.62 for unenhanced sequences.

CONCLUSION: Optimized SPIO-enhanced T2-weighted GRE combined with unenhanced T2-weighted FSE MR sequences were the most sensitive. Breath-hold FSE postcontrast sequences offer no improvement in sensitivity compared with unenhanced sequences alone.

Item Type: Article
Copyright, Publisher and Additional Information: Copyright © 2006 Radiological Society of North America.
Keywords: liver neoplasms; metastases; magnetic resonance imaging; contrast enhancement; contrast media; iron
Institution: The University of Leeds
Academic Units: The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Healthcare (Leeds) > Imaging Science (Leeds)
Depositing User: Paul M Arnold
Date Deposited: 13 Oct 2006
Last Modified: 01 Jul 2014 04:15
Published Version: http://radiology.rsnajnls.org/cgi/content/abstract...
Status: Published
Publisher: Radiological Society of North America
Refereed: Yes
Identification Number: 10.1148/radiol.2283020376
URI: http://eprints.whiterose.ac.uk/id/eprint/1640

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