Edmans, J.G., Clitherow, K.H., Murdoch, C. orcid.org/0000-0001-9724-122X et al. (3 more authors) (2020) Mucoadhesive electrospun fibre-based technologies for oral medicine. Pharmaceutics, 12 (6). 504. ISSN 1999-4923
Abstract
Oral disease greatly affects quality of life, as the mouth is required for a wide range of activities including speech, food and liquid consumption. Treatment of oral disease is greatly limited by the dose forms that are currently available, which suffer from short contact times, poor site specificity, and sensitivity to mechanical stimulation. Mucoadhesive devices prepared using electrospinning offer the potential to address these challenges by allowing unidirectional site-specific drug delivery through intimate contact with the mucosa and with high surface areas to facilitate drug release. This review will discuss the range of electrospun mucoadhesive devices that have recently been reported to address oral inflammatory diseases, pain relief, and infections, as well as new treatments that are likely to be enabled by this technology in the future.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2020 The Authors. This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. https://creativecommons.org/licenses/by/4.0/ |
Keywords: | bioadhesion; drug delivery; electrospinning; infections; inflammation; local therapy; mucosa; oral cavity; pain relief |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Clinical Dentistry (Sheffield) The University of Sheffield > Faculty of Science (Sheffield) > Department of Chemistry (Sheffield) |
Funding Information: | Funder Grant number Engineering and Physical Sciences Research Council EP/L016281/1 |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 15 Jun 2020 20:04 |
Last Modified: | 15 Jun 2020 20:04 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.3390/pharmaceutics12060504 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:161764 |