Ulamec, SM and Radford, SE orcid.org/0000-0002-3079-8039 (2020) Spot the Difference: Function versus Toxicity in Amyloid Fibrils. Trends in Biochemical Sciences. ISSN 0968-0004
Abstract
In a recent study, Hervas et al. extracted Orb2 fibrils, that are involved in long-term memory formation, from Drosophila brains, characterised their function, and determined their structure using cryo-electron microscopy (cryo-EM). The fibrils show a remarkable resemblance to amyloid β (Aβ) fibrils associated with Alzheimer’s disease, highlighting the subtle difference between functional and dysfunctional amyloid.
Metadata
Authors/Creators: |
|
||||
---|---|---|---|---|---|
Copyright, Publisher and Additional Information: | © 2020 Elsevier Ltd. This is an author produced version of a paper published in Trends in Biochemical Sciences. Uploaded in accordance with the publisher's self-archiving policy. | ||||
Keywords: | amyloid; cryo-electron microscopy; Orb2; CPEB; Alzheimer; memory | ||||
Dates: |
|
||||
Institution: | The University of Leeds | ||||
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Molecular and Cellular Biology (Leeds) > Structural Molecular Biology (Leeds) | ||||
Funding Information: |
|
||||
Depositing User: | Symplectic Publications | ||||
Date Deposited: | 23 Apr 2020 10:50 | ||||
Last Modified: | 03 May 2021 00:38 | ||||
Status: | Published online | ||||
Publisher: | Elsevier | ||||
Identification Number: | https://doi.org/10.1016/j.tibs.2020.04.007 |