Farzi, M., Pozo, J.M., McCloskey, E. orcid.org/0000-0003-0177-8140 et al. (4 more authors) (2020) A spatio-temporal ageing atlas of the proximal femur. IEEE Transactions on Medical Imaging, 39 (5). pp. 1359-1368. ISSN 0278-0062
Abstract
Osteoporosis is an age-associated disease characterised by low bone mineral density (BMD) and microarchitectural deterioration leading to enhanced fracture risk. Conventional dual-energy X-ray absorptiometry (DXA) analysis has facilitated our understanding of BMD reduction in specific regions of interest (ROIs) within the femur, but cannot resolve spatial BMD patterns nor reflect age-related changes in bone microarchitecture due to its inherent averaging of pixel BMD values into large ROIs. To address these limitations and develop a comprehensive model of involutional bone loss, this paper presents a fully automatic pipeline to build a spatio-temporal atlas of ageing bone in the proximal femur. A new technique, termed DXA region free analysis (DXA RFA), is proposed to eliminate morphological variation between DXA scans by warping each image into a reference template. To construct the atlas, we use unprocessed DXA data from Caucasian women aged 20-97 years participating in three cohort studies in Western Europe (n>13,000). A novel calibration procedure, termed quantile matching regression, is proposed to integrate data from different DXA manufacturers. Pixel-wise BMD evolution with ageing was modelled using smooth quantile curves. This technique enables characterisation of spatially-complex BMD change patterns with ageing, visualised using heat-maps. Furthermore, quantile curves plotted at different pixel coordinates showed consistently different rates of bone loss at different regions within the femoral neck. Given the close relationship between spatio-temporal bone loss and osteoporotic fracture, improved understanding of the bone ageing process could lead to enhanced prognostic, preventive and therapeutic strategies for the disease.
Metadata
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Copyright, Publisher and Additional Information: | © 2019 IEEE. This work is licensed under a Creative Commons Attribution 4.0 License. For more information, see https://creativecommons.org/licenses/by/4.0/. | ||||
Keywords: | Spatio-temporal Atlas; DXA; Region Free Analysis; Osteoporosis | ||||
Dates: |
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Institution: | The University of Sheffield | ||||
Academic Units: | The University of Sheffield > Sheffield Teaching Hospitals | ||||
Funding Information: |
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Depositing User: | Symplectic Sheffield | ||||
Date Deposited: | 22 Apr 2020 11:43 | ||||
Last Modified: | 26 Nov 2021 14:46 | ||||
Status: | Published | ||||
Publisher: | Institute of Electrical and Electronics Engineers (IEEE) | ||||
Refereed: | Yes | ||||
Identification Number: | https://doi.org/10.1109/tmi.2019.2945219 | ||||
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