Comprehensive cancer-predisposition gene testing in an adult multiple primary tumor series shows a broad range of deleterious variants and atypical tumor phenotypes

Whitworth, J, Smith, PS, Martin, J-E et al. (330 more authors) (2018) Comprehensive cancer-predisposition gene testing in an adult multiple primary tumor series shows a broad range of deleterious variants and atypical tumor phenotypes. The American Journal of Human Genetics, 103 (1). pp. 3-18. ISSN 0002-9297

Abstract

Metadata

Authors/Creators:
  • Whitworth, J
  • Smith, PS
  • Martin, J-E
  • West, H
  • Luchetti, A
  • Rodger, F
  • Clark, G
  • Carss, K
  • Stephens, J
  • Stirrups, K
  • Penkett, C
  • Mapeta, R
  • Ashford, S
  • Megy, K
  • Shakeel, H
  • Ahmed, M
  • Adlard, J
  • Barwell, J
  • Brewer, C
  • Casey, RT
  • Armstrong, R
  • Cole, T
  • Evans, DG
  • Fostira, F
  • Greenhalgh, L
  • Hanson, H
  • Henderson, A
  • Hoffman, J
  • Izatt, L
  • Kumar, A
  • Kwong, A
  • Lalloo, F
  • Ong, KR
  • Paterson, J
  • Park, S-M
  • Chen-Shtoyerman, R
  • Searle, C
  • Side, L
  • Skytte, A-B
  • Snape, K
  • Woodward, ER
  • Tischkowitz, MD
  • Maher, ER
  • Aitman, T
  • Alachkar, H
  • Ali, S
  • Allen, L
  • Allsup, D
  • Ambegaonkar, G
  • Anderson, J
  • Antrobus, R
  • Armstrong, R
  • Arno, G
  • Arumugakani, G
  • Ashford, S
  • Astle, W
  • Attwood, A
  • Austin, S
  • Bacchelli, C
  • Bakchoul, T
  • Bariana, TK
  • Baxendale, H
  • Bennett, D
  • Bethune, C
  • Bibi, S
  • Bitner-Glindzicz, M
  • Bleda, M
  • Boggard, H
  • Bolton-Maggs, P
  • Booth, C
  • Bradley, JR
  • Brady, A
  • Brown, M
  • Browning, M
  • Bryson, C
  • Burns, S
  • Calleja, P
  • Canham, N
  • Carmichael, J
  • Carss, K
  • Caulfield, M
  • Chalmers, E
  • Chandra, A
  • Chinnery, P
  • Chitre, M
  • Church, C
  • Clement, E
  • Clements-Brod, N
  • Clowes, V
  • Coghlan, G
  • Collins, P
  • Cookson, V
  • Cooper, N
  • Corris, P
  • Creaser-Myers, A
  • DaCosta, R
  • Daugherty, L
  • Davies, S
  • Davis, J
  • De Vries, M
  • Deegan, P
  • Deevi, SVV
  • Deshpande, C
  • Devlin, L
  • Dewhurst, E
  • Dixon, P
  • Doffinger, R
  • Dormand, N
  • Drewe, E
  • Edgar, D
  • Egner, W
  • Erber, WN
  • Erwood, M
  • Erwood, M
  • Everington, T
  • Favier, R
  • Firth, H
  • Fletcher, D
  • Flinter, F
  • Frary, A
  • Freson, K
  • Furie, B
  • Furnell, A
  • Gale, D
  • Gardham, A
  • Gattens, M
  • Ghali, N
  • Ghataorhe, PK
  • Ghurye, R
  • Gibbs, S
  • Gilmour, K
  • Gissen, P
  • Goddard, S
  • Gomez, K
  • Gordins, P
  • Graf, S
  • Gräf, S
  • Greene, D
  • Greenhalgh, A
  • Greinacher, A
  • Grigoriadou, S
  • Grozeva, D
  • Hackett, S
  • Hadinnapola, C
  • Hague, R
  • Haimel, M
  • Halmagyi, C
  • Hammerton, T
  • Hart, D
  • Hayman, G
  • Heemskerk, JWM
  • Henderson, R
  • Hensiek, A
  • Henskens, Y
  • Herwadkar, A
  • Holden, S
  • Holder, M
  • Holder, S
  • Hu, F
  • Huis in’t Veld, A
  • Huissoon, A
  • Humbert, M
  • Hurst, J
  • James, R
  • Jolles, S
  • Josifova, D
  • Kazmi, R
  • Keeling, D
  • Kelleher, P
  • Kelly, AM
  • Kennedy, F
  • Kiely, D https://orcid.org/0000-0003-0184-6502
  • Kingston, N
  • Koziell, A
  • Krishnakumar, D
  • Kuijpers, TW
  • Kuijpers, T
  • Kumararatne, D
  • Kurian, M
  • Laffan, MA
  • Lambert, MP
  • Allen, HL
  • Lango-Allen, H
  • Lawrie, A
  • Lear, S
  • Lees, M
  • Lentaigne, C
  • Liesner, R
  • Linger, R
  • Longhurst, H
  • Lorenzo, L
  • Louka, E
  • Machado, R
  • Ross, RM
  • MacLaren, R
  • Maher, E
  • Maimaris, J
  • Mangles, S
  • Manson, A
  • Mapeta, R
  • Markus, HS
  • Martin, J
  • Masati, L
  • Mathias, M
  • Matser, V
  • Maw, A
  • McDermott, E
  • McJannet, C
  • Meacham, S
  • Meehan, S
  • Megy, K
  • Mehta, S
  • Michaelides, M
  • Millar, CM
  • Moledina, S
  • Moore, A
  • Morrell, N
  • Mumford, A
  • Murng, S
  • Murphy, E
  • Nejentsev, S
  • Noorani, S
  • Nurden, P
  • Oksenhendler, E
  • Othman, S
  • Ouwehand, WH
  • Ouwehand, WH
  • Papadia, S
  • Park, S-M
  • Parker, A
  • Pasi, J
  • Patch, C
  • Paterson, J
  • Payne, J
  • Peacock, A
  • Peerlinck, K
  • Penkett, CJ
  • Pepke-Zaba, J
  • Perry, D
  • Perry, DJ
  • Pollock, V
  • Polwarth, G
  • Ponsford, M
  • Qasim, W
  • Quinti, I
  • Rankin, S
  • Rankin, J
  • Raymond, FL
  • Rayner-Matthews, P
  • Rehnstrom, K
  • Reid, E
  • Rhodes, CJ
  • Richards, M
  • Richardson, S
  • Richter, A
  • Roberts, I
  • Rondina, M
  • Rosser, E
  • Roughley, C
  • Roy, N
  • Rue-Albrecht, K
  • Samarghitean, C
  • Sanchis-Juan, A
  • Sandford, R
  • Santra, S
  • Sargur, R
  • Savic, S
  • Schotte, G
  • Schulman, S
  • Schulze, H
  • Scott, R
  • Scully, M
  • Seneviratne, S
  • Sewell, C
  • Shamardina, O
  • Shipley, D
  • Simeoni, I
  • Sivapalaratnam, S
  • Smith, KGC
  • Sohal, A
  • Southgate, L
  • Staines, S
  • Staples, E
  • Stark, H
  • Stauss, H
  • Stein, P
  • Stephens, J
  • Stirrups, K
  • Stock, S
  • Suntharalingam, J
  • Talks, K
  • Tan, Y
  • Thachil, J
  • Thaventhiran, J
  • Thomas, E
  • Thomas, M
  • Thompson, D
  • Thrasher, A
  • Tischkowitz, M
  • Titterton, C
  • Toh, C-H
  • Toshner, M
  • Treacy, C
  • Trembath, R
  • Tuna, S
  • Turek, W
  • Turro, E
  • Van Geet, C
  • Veltman, M
  • Vogt, J
  • von Ziegenweldt, J
  • Vonk Noordegraaf, A
  • Wakeling, E
  • Wanjiku, I
  • Warner, TQ
  • Wassmer, E
  • Watkins, H
  • Watt, C
  • Webster, N
  • Welch, S
  • Westbury, S
  • Wharton, J
  • Whitehorn, D
  • Wilkins, M
  • Willcocks, L
  • Williamson, C
  • Woods, G
  • Woods, G
  • Wort, J
  • Yeatman, N
  • Yong, P
  • Young, T
  • Yu, P
Copyright, Publisher and Additional Information: © 2018 The Authors. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: cancer-predisposition syndromes; inherited cancer genetics; genetic testing; whole genome sequencing
Dates:
  • Accepted: 25 April 2018
  • Published (online): 14 June 2018
  • Published: 5 July 2018
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Sheffield Teaching Hospitals
Depositing User: Symplectic Sheffield
Date Deposited: 18 Feb 2020 09:13
Last Modified: 19 Feb 2020 15:08
Status: Published
Publisher: Elsevier
Refereed: Yes
Identification Number: https://doi.org/10.1016/j.ajhg.2018.04.013
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