Ferreira, S.B.D.S., Braga, G., Oliveira, É.L. et al. (8 more authors) (2019) Design of a nanostructured mucoadhesive system containing curcumin for buccal application : from physicochemical to biological aspects. Beilstein Journal of Nanotechnology, 10. pp. 2304-2328. ISSN 2190-4286
Abstract
Mucoadhesive nanostructured systems comprising poloxamer 407 and Carbopol 974P® have already demonstrated good mucoadhesion, as well as improved mechanical and rheological properties. Curcumin displays excellent biological activity, mainly in oral squamous cancer; however, its physicochemical characteristics hinder its application. Therefore, the aim of this study was to develop nanostructured formulations containing curcumin for oral cancer therapy. The photophysical interactions between curcumin and the formulations were elucidated by incorporation kinetics and location studies. They revealed that the drug was quickly incorporated and located in the hydrophobic portion of nanometer-sized polymeric micelles. Moreover, the systems displayed plastic behavior with rheopexy characteristics at 37 °C, viscoelastic properties and a gelation temperature of 36 °C, which ensures increased retention after application in the oral cavity. The mucoadhesion results confirmed the previous findings with the nanostructured systems showing a residence time of 20 min in porcine oral mucosa under flow system conditions. Curcumin was released after 8 h and could permeate through the porcine oral mucosa. Cytotoxicity testing revealed that the formulations were selective to cancer cells over healthy cells. Therefore, these systems could improve the physicochemical characteristics of curcumin by providing improved release and permeation, while selectivity targeting cancer cells.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2019 The Authors. This is an Open Access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0). Please note that the reuse, redistribution and reproduction in particular requires that the authors and source are credited. |
Keywords: | curcumin; mucoadhesion; oral squamous cell carcinoma; permeation; poloxamer 407 |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Clinical Dentistry (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 20 Jan 2020 15:44 |
Last Modified: | 20 Jan 2020 15:44 |
Status: | Published |
Publisher: | Beilstein Institut |
Refereed: | Yes |
Identification Number: | 10.3762/bjnano.10.222 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:155417 |