Lane, C., Tatton-Brown, K. and Freeth, M. orcid.org/0000-0003-0534-9095 (2020) Tatton-Brown-Rahman syndrome : cognitive and behavioural phenotypes. Developmental Medicine & Child Neurology, 62 (8). pp. 993-998. ISSN 0012-1622
Abstract
The aim of this case series was to assess and characterise cognitive abilities, autistic traits and adaptive behaviour in Tatton-Brown-Rahman syndrome. The sample included 18 individuals with a clinical and genetic diagnosis of TBRS (11 males, seven females; mean age 17y 7mo, SD 9y 5mo, range 7y 2mo–33y 10mo). The British Ability Scales, Third Edition and the Autism Diagnostic Observation Schedule, Second Edition (ADOS-2) were administered to all participants. The Social Responsiveness Scale, Second Edition and the Vineland Adaptive Behaviour Scales, Third Edition were completed by a parent/caregiver. The majority of participants (n=15) had intellectual disability and General Conceptual Ability scores ranged from 39 - 76 (mean 53.17, SD 12.13). Participants displayed a profile of better verbal ability compared with non-verbal reasoning ability and spatial ability. Autistic traits were prevalent and eight participants scored above the cut-off on the ADOS-2, though symptoms were less pronounced in older individuals. Adaptive functioning was impaired but commensurate with intellectual ability. Overall, TBRS is associated with an uneven cognitive profile and a high prevalence of autistic traits. This has implications for identifying appropriate services and support which may be beneficial for individuals with TBRS.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2019 Mac Keith Press. This is an author-produced version of a paper subsequently published in Developmental Medicine and Child Neurology. Uploaded in accordance with the publisher's self-archiving policy. |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Science (Sheffield) > Department of Psychology (Sheffield) |
Funding Information: | Funder Grant number Baily Thomas Foundation TRUST/VC/AC/SG/4684-7599 |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 14 Nov 2019 14:06 |
Last Modified: | 17 Dec 2021 11:23 |
Status: | Published |
Publisher: | Wiley |
Refereed: | Yes |
Identification Number: | 10.1111/dmcn.14426 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:153423 |