Metformin promotes antitumor immunity via endoplasmic-reticulum-associated degradation of PD-L1

Cha, J.-H., Yang, W.-H., Xia, W. et al. (25 more authors) (2018) Metformin promotes antitumor immunity via endoplasmic-reticulum-associated degradation of PD-L1. Molecular Cell, 71 (4). 606-620.e7. ISSN 1097-2765

Abstract

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Authors/Creators:
  • Cha, J.-H.
  • Yang, W.-H.
  • Xia, W.
  • Wei, Y.
  • Chan, L.-C.
  • Lim, S.-O.
  • Li, C.-W.
  • Kim, T.
  • Chang, S.-S.
  • Lee, H.-H.
  • Hsu, J.L.
  • Wang, H.-L.
  • Kuo, C.-W.
  • Chang, W.-C.
  • Hadad, S. https://orcid.org/0000-0002-9190-021X
  • Purdie, C.A.
  • McCoy, A.M.
  • Cai, S.
  • Tu, Y.
  • Litton, J.K.
  • Mittendorf, E.A.
  • Moulder, S.L.
  • Symmans, W.F.
  • Thompson, A.M.
  • Piwnica-Worms, H.
  • Chen, C.-H.
  • Khoo, K.-H.
  • Hung, M.-C.
Copyright, Publisher and Additional Information: © 2018 Elsevier. Uploaded in accordance with the publisher's self-archiving policy.
Keywords: metformin; PD-L1; glycosylation; ER accumulation; ERAD; immune checkpoint blockade; cancer immunotherapy
Dates:
  • Accepted: 23 July 2018
  • Published (online): 16 August 2018
  • Published: 16 August 2018
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > Department of Human Metabolism (Sheffield)
The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > Department of Oncology (Sheffield)
Depositing User: Symplectic Sheffield
Date Deposited: 14 Oct 2019 13:19
Last Modified: 14 Oct 2019 14:13
Status: Published
Publisher: Elsevier
Refereed: Yes
Identification Number: https://doi.org/10.1016/j.molcel.2018.07.030
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