Discovery of N-methylpiperazinyl flavones as a novel class of compounds with therapeutic potential against Alzheimer’s disease : synthesis, binding affinity towards amyloid β oligomers (Aβo) and ability to disrupt Aβo-PrPC interactions

Matos, A.M., Man, T., Idrissi, I. et al. (13 more authors) (2019) Discovery of N-methylpiperazinyl flavones as a novel class of compounds with therapeutic potential against Alzheimer’s disease : synthesis, binding affinity towards amyloid β oligomers (Aβo) and ability to disrupt Aβo-PrPC interactions. Pure and Applied Chemistry, 91 (7). pp. 1107-1136. ISSN 0033-4545

Abstract

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Authors/Creators:
Copyright, Publisher and Additional Information: ©2019 IUPAC & De Gruyter. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. For more information, please visit: http://creativecommons.org/licenses/by-nc-nd/4.0/.
Keywords: Aβo-PrPC interaction disruptors; Alzheimer’s disease; C-glucosylation; flavones; ICS-29
Dates:
  • Published (online): 29 April 2019
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Science (Sheffield) > Department of Chemistry (Sheffield)
The University of Sheffield > Sheffield Teaching Hospitals
Funding Information:
FunderGrant number
ALZHEIMER'S SOCIETY248 (AS-JF-14-001)
Depositing User: Symplectic Sheffield
Date Deposited: 06 Nov 2019 12:35
Last Modified: 07 Nov 2019 08:22
Status: Published online
Publisher: De Gruyter
Refereed: Yes
Identification Number: https://doi.org/10.1515/pac-2019-0114

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