Bowes, MA, Lohmander, LS, Wolstenholme, CBH et al. (3 more authors) (2019) Marked and Rapid Change of Bone Shape In Acutely Acl Injured Knees – An Exploratory Analysis Of The Kanon Trial. Osteoarthritis and Cartilage, 27 (4). pp. 638-645. ISSN 1522-9653
Abstract
Background
To investigate changes in knee 3D bone shape over the first 5 years after acute anterior cruciate ligament (ACL) injury in participants of the randomized controlled KANON-trial.
Methods
Serial MR images over 5 years from 121 young (32 women, mean age 26.1 years) adults with an acute ACL tear in a previously un-injured knee were analyzed using statistical shape models for bone. A matched reference cohort of 176 individuals was selected from the Osteoarthritis Initiative (OAI). Primary endpoint was change in bone area of the medial femoral condyle; exploratory analyses compared results by treatment and examined other knee regions. Comparisons were made using repeated measures mixed model ANOVA with adjustment for age, sex and BMI.
Results
Mean medial femur bone area increased 3.2% (78.0 [95% CI 70.2 to 86.4] mm2) over 5 years after ACL injury and most prominently in knees treated with ACL reconstruction. A higher rate of increase occurred over the first two years compared to the latter three-years (66.2 [59.3 to 73.2] vs. 17.6 [12.2 to 23.0] mm2) and was 6.7 times faster than in the reference cohort. The pattern and location of shape change in the extrapolated KANON data was very similar to that observed in another knee-osteoarthritis cohort.
Conclusion
3D shape modelling after acute ACL injury revealed rapid bone shape changes, already evident at 3 months. The bone-change pattern after ACL injury demonstrated flattening and bone growth on the outer margins of the condyles similar to that reported in established knee osteoarthritis.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2019 Published by Elsevier Ltd on behalf of Osteoarthritis Research Society International. This is an author produced version of a paper published in Osteoarthritis and Cartilage. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | ACL tear; bone shape; osteoarthritis |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Institute of Rheumatology & Musculoskeletal Medicine (LIRMM) (Leeds) > Musculoskeletal Medicine & Imaging (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 07 Jan 2019 14:29 |
Last Modified: | 14 Jan 2020 01:39 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.joca.2018.12.021 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:140476 |
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Filename: Bowes KANON paper accepted version in Word.pdf
Licence: CC-BY-NC-ND 4.0