Ho, Hon Eong orcid.org/0000-0003-1037-2505, Stephens, Thomas Christian, Payne, Thomas et al. (3 more authors) (2019) Merging π-Acid and Pd Catalysis : Dearomatizing Spirocyclization/Cross-Coupling Cascade Reactions of Alkyne-Tethered Aromatics. ACS Catalysis. pp. 504-510. ISSN 2155-5435
Abstract
A one-pot protocol for the dearomatising spirocyclisation/cross coupling of alkyne-tethered indoles/pyrroles is described. Mechanistic studies support a process by which palladium complexes generated in situ act as both π-acid and cross coupling catalysts. Overall, this facilitates an efficient cascade process that enables the simultaneous preparation of synthetically challenging quaternary spirocyclic carbons and tetrasubstituted alkenes in a single operation. KEYWORDS spirocycles, dearomatisation, cross coupling, palladium, catalysis
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Copyright, Publisher and Additional Information: | © 2018 American Chemical Society. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details. | ||||
Keywords: | catalysis, cross-coupling, dearomatization, palladium, spirocycles | ||||
Dates: |
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Institution: | The University of York | ||||
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) | ||||
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Depositing User: | Pure (York) | ||||
Date Deposited: | 06 Dec 2018 12:40 | ||||
Last Modified: | 06 Dec 2023 12:52 | ||||
Published Version: | https://doi.org/10.1021/acscatal.8b03861 | ||||
Status: | Published | ||||
Refereed: | Yes | ||||
Identification Number: | https://doi.org/10.1021/acscatal.8b03861 | ||||
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Filename: Ho_Pd_spiro_ACS_template_version_8_revision.docx
Description: Ho Pd spiro ACS template version 8 revision