Hyperpolarised xenon magnetic resonance spectroscopy for the longitudinal assessment of changes in gas diffusion in IPF

Abstract

Prognosticating idiopathic pulmonary fibrosis (IPF) is challenging, in part due to a lack of sensitive biomarkers. A recent article in Thorax described how hyperpolarised xenon magnetic resonance spectroscopy may quantify regional gas exchange in IPF lungs. In a population of patients with IPF, we find that the xenon signal from red blood cells diminishes relative to the tissue/plasma signal over a 12-month time period, even when the diffusion factor for carbon monoxide is static over the same time period. We conclude that hyperpolarised 129Xe MR spectroscopy may be sensitive to short-term changes in interstitial gas diffusion in IPF.

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Item Type:	Article
Authors/Creators:	Weatherley, N.D. https://orcid.org/0000-0001-5589-2219 Stewart, N.J. Chan, H.-F. Austin, M. Smith, L.J. https://orcid.org/0000-0002-5769-423X Collier, G. Rao, M. Marshall, H. Norquay, G. Renshaw, S.A. https://orcid.org/0000-0003-1790-1641 Bianchi, S.M. Wild, J.M. https://orcid.org/0000-0002-7246-8660
Copyright, Publisher and Additional Information:	© Author(s) (or their employer(s)) 2018. Re-use permitted under CC BY. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.
Dates:	Published: 11 April 2019 Published (online): 2 November 2018 Accepted: 8 October 2018
Institution:	The University of Sheffield
Academic Units:	The University of Sheffield > Sheffield Teaching Hospitals
Funding Information:	Funder Grant number NATIONAL INSTITUTE FOR HEALTH RESEARCH ICA-CDRF-2015-01-027 EUROPEAN COMMISSION - HORIZON 2020 UNSPECIFIED
Depositing User:	Symplectic Sheffield
Date Deposited:	24 Jan 2019 15:30
Last Modified:	02 Nov 2021 10:50
Status:	Published
Publisher:	BMJ Publishing Group
Refereed:	Yes
Identification Number:	10.1136/thoraxjnl-2018-211851
Related URLs:	PubMed URL
Open Archives Initiative ID (OAI ID):	oai:eprints.whiterose.ac.uk:138920

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Hyperpolarised xenon magnetic resonance spectroscopy for the longitudinal assessment of changes in gas diffusion in IPF

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