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Tissue Cytokine Responses in Canine Visceral Leishmaniasis

Quinnell, R.J., Courtenay, O., Shaw, M.-A., Day, M.J., Garcez, L.M., Dye, C. and Kaye, P.M. (2001) Tissue Cytokine Responses in Canine Visceral Leishmaniasis. The Journal of Infectious Diseases, 183 (9). pp. 1421-1424. ISSN 0022-1899

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Abstract

To elucidate the local tissue cytokine response of dogs infected with Leishmania chagasi, cytokine mRNA levels were measured in bone marrow aspirates from 27 naturally infected dogs from Brazil and were compared with those from 5 uninfected control animals. Interferon-γ mRNA accumulation was enhanced in infected dogs and was positively correlated with humoral (IgG1) but not with lymphoproliferative responses to Leishmania antigen in infected dogs. Increased accumulation of mRNA for interleukin (IL)4, IL-10, and IL-18 was not observed in infected dogs, and mRNA for these cytokines did not correlate with antibody or proliferative responses. However, infected dogs with detectable IL-4 mRNA had significantly more severe symptoms. IL-13 mRNA was not detectable in either control or infected dogs. These data suggest that clinical symptoms are not due to a deficiency in interferon-γ production. However, in contrast to its role in human visceral leishmaniasis, IL-10 may not play a key immunosuppressive role in dogs.

Item Type: Article
Copyright, Publisher and Additional Information: © 2001 by the Infectious Diseases Society of America. Reproduced in accordance with the publisher's self-archiving policy.
Institution: The University of Leeds
Academic Units: The University of Leeds > Faculty of Biological Sciences (Leeds) > Institute of Integrative and Comparative Biology (Leeds)
Depositing User: Repository Officer
Date Deposited: 26 Jun 2006
Last Modified: 10 Jun 2014 03:39
Published Version: http://www.journals.uchicago.edu/JID/journal/issue...
Status: Published
Publisher: The University of Chicago
Refereed: Yes
URI: http://eprints.whiterose.ac.uk/id/eprint/1378

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