Quinnell, R.J., Pritchard, D.I., Raiko, A., Brown, A.P. and Shaw, M.-A. (2004) Immune Responses in Human Necatoriasis: Association between Interleukin-5 Responses and Resistance to Reinfection. The Journal of Infectious Diseases, 190 (3). pp. 430-438. ISSN 0022-1899Full text available as:
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Cytokine and proliferative responses to Necator americanus infection were measured in a treatment-reinfection study of infected subjects from an area of Papua New Guinea where N. americanus is highly endemic. Before treatment, most subjects produced detectable interleukin (IL)4 (97%), IL-5 (86%), and interferon (IFN)-γ(64%) in response to adult N. americanus antigen. Pretreatment IFN-γ responses were negatively associated with hookworm burden, decreasing by 18 pg/mL for each increase of 1000 eggs/gram (epg) (n = 75; P < .01). Mean IFN-γ responses increased significantly after anthelmintic treatment, from 166 to 322 pg/mL (n = 42; P < .01). The intensity of reinfection was significantly negatively correlated with pretreatment IL-5 responses, decreasing by 551 epg for each 100 pg/mL increase in production of IL-5 (n = 51; P < .01). These data indicate that there is a mixed cytokine response in necatoriasis, with worm burdenassociated suppression of IFN-γ responses to adult N. americanus antigen. Resistance to reinfection is associated with the parasite-specific IL-5 response.
|Copyright, Publisher and Additional Information:||© 2004 by the Infectious Diseases Society of America. Reproduced in accordance with the publisher's self-archiving policy.|
|Institution:||The University of Leeds|
|Academic Units:||The University of Leeds > Faculty of Biological Sciences (Leeds) > Institute of Integrative and Comparative Biology (Leeds)|
|Depositing User:||Repository Officer|
|Date Deposited:||26 Jun 2006|
|Last Modified:||06 Jun 2014 16:13|
|Publisher:||The University of Chicago|