Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

Mills, EL, Ryan, DG, Prag, HA et al. (32 more authors) (2018) Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1. Nature, 556 (7699). pp. 113-117. ISSN 0028-0836

Abstract

Metadata

Authors/Creators:
  • Mills, EL
  • Ryan, DG
  • Prag, HA
  • Dikovskaya, D
  • Menon, D
  • Zaslona, Z
  • Jedrychowski, MP
  • Costa, ASH
  • Higgins, M
  • Hams, E
  • Szpyt, J
  • Runtsch, MC
  • King, MS
  • McGouran, JF
  • Fischer, R
  • Kessler, BM
  • McGettrick, AF
  • Hughes, MM
  • Carroll, RG
  • Booty, LM
  • Knatko, EV
  • Meakin, PJ https://orcid.org/0000-0002-8553-3863
  • Ashford, MLJ
  • Modis, LK
  • Brunori, G
  • Sévin, DC
  • Fallon, PG
  • Caldwell, ST
  • Kunji, ERS
  • Chouchani, ET
  • Frezza, C
  • Dinkova-Kostova, AT
  • Hartley, RC
  • Murphy, MP
  • O’Neill, LA
Dates:
  • Published: 5 April 2018
  • Accepted: 9 February 2018
  • Published (online): 28 March 2018
Institution: The University of Leeds
Academic Units: The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM) > Discovery & Translational Science Dept (Leeds)
Depositing User: Symplectic Publications
Date Deposited: 04 Oct 2018 10:16
Last Modified: 27 Jan 2020 16:46
Status: Published
Publisher: Springer Nature
Identification Number: https://doi.org/10.1038/nature25986
Related URLs:

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