Ash, Z, Tan, AL orcid.org/0000-0002-9158-7243, Hodgson, RJ et al. (3 more authors) (2018) MRI of psoriatic nail disease pre- and post-TNF inhibitor therapy shows persistent subclinical inflammation after 6 months despite good clinical response. RMD Open, 4 (1). e000599. ISSN 2056-5933
Abstract
What is already known about this subject?
Nail involvement is part of the clinical spectrum of psoriatic arthritis and responds to tumour necrosis factor (TNF) inhibitors.
What does this study add?
This small study assessed patients with psoriatic arthritis with nail disease and active distal interphalangeal (DIP) arthritis before and after 6 months of TNF inhibitor treatment.
Persistent inflammatory changes in and around the DIP joint were seen on follow-up MRI scans despite a good clinical response.
How might this impact on clinical practice?
Further studies are needed to see whether these inflammatory changes resolve with a longer duration of treatment or relate to radiographic progression of the arthritis.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted. this is an open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/ licenses/by-nc/4.0/ |
Dates: |
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Institution: | The University of Leeds |
Depositing User: | Symplectic Publications |
Date Deposited: | 24 Sep 2018 12:11 |
Last Modified: | 24 Sep 2018 12:11 |
Status: | Published |
Publisher: | BMJ |
Identification Number: | 10.1136/rmdopen-2017-000599 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:136107 |