Stephens, Thomas C, Lawer, Aggie, French, Thomas et al. (1 more author) (2018) Iterative Assembly of Macrocyclic Lactones using Successive Ring Expansion Reactions. Chemistry : A European Journal. pp. 13947-13953. ISSN 1521-3765
Abstract
Macrocyclic lactones can be prepared from lactams and hydroxyacid derivatives via an efficient 3- or 4-atom iterative ring expansion protocol. The products can also be expanded using amino acid-based linear fragments, meaning that macrocycles with precise sequences of hydroxy- and amino acids can be assembled in high yields by 'growing' them from smaller rings, using a simple procedure in which high dilution is not required. The method should significantly expedite the practical synthesis of diverse nitrogen containing macrolide frameworks.
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Copyright, Publisher and Additional Information: | © 2018 The Authors. | ||||
Keywords: | Journal Article | ||||
Dates: |
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Institution: | The University of York | ||||
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) | ||||
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Depositing User: | Pure (York) | ||||
Date Deposited: | 18 Jul 2018 08:40 | ||||
Last Modified: | 11 Feb 2024 00:31 | ||||
Published Version: | https://doi.org/10.1002/chem.201803064 | ||||
Status: | Published | ||||
Refereed: | Yes | ||||
Identification Number: | https://doi.org/10.1002/chem.201803064 | ||||
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