Maiden, T.M.M., Mbelesi, N., Procopiou, P.A. orcid.org/0000-0001-5907-116X et al. (2 more authors) (2018) A convergent strategy towards febrifugine and related compounds. Organic and Biomolecular Chemistry, 16 (22). pp. 4159-4169. ISSN 1477-0520
Abstract
We report a modular five step synthetic route to the febrifugines that employs 2-(chloromethyl)allyl-trimethylsilane as a conjunctive reagent for the coupling of the piperidine and quinazolinone groups. We also demonstrate the application of a recent Rh-catalyzed quinazolinone synthesis for the facile generation of febrifugine analogs.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2018 The Royal Society of Chemistry. This is an author produced version of a paper subsequently published in Organic and Biomolecular Chemistry. Uploaded in accordance with the publisher's self-archiving policy. |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Science (Sheffield) > Department of Chemistry (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 30 May 2018 13:04 |
Last Modified: | 19 Apr 2021 09:48 |
Status: | Published |
Publisher: | Royal Society of Chemistry |
Refereed: | Yes |
Identification Number: | 10.1039/c8ob00935j |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:131397 |