Novodvorsky, P. orcid.org/0000-0002-3292-7586 and Chico, T.J.A. orcid.org/0000-0002-7458-5481 (2014) The Role of the Transcription Factor KLF2 in Vascular Development and Disease. Progress in Molecular Biology and Translational Science, 124. pp. 155-188. ISSN 1877-1173
Abstract
The zinc-finger transcription factor KLF2 transduces the physical forces exerted by blood flow into molecular signals responsible for a wide range of biological responses. Following its initial recognition as a flow-responsive endothelial transcription factor, KLF2 is now known to be expressed in a range of cell types and to participate in a number of processes during development and disease such as endothelial homeostasis, vasoregulation, vascular growth/remodeling, and inflammation. In this review, we summarize the current understanding about KLF2 with a focus on its effects on vascular biology.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2014 Elsevier |
Keywords: | KLF2; Shear stress; Endothelium; Atherosclerosis; Angiogenesis; Vasculogenesis; Valvulogenesis |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Sheffield Teaching Hospitals |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 18 Jun 2018 10:48 |
Last Modified: | 18 Jun 2018 10:48 |
Published Version: | https://doi.org/10.1016/B978-0-12-386930-2.00007-0 |
Status: | Published |
Publisher: | Elsevier |
Refereed: | Yes |
Identification Number: | 10.1016/B978-0-12-386930-2.00007-0 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:131325 |
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