Novodvorsky, P. orcid.org/0000-0002-3292-7586, Da Costa, M.M.J. orcid.org/0000-0002-3804-0150 and Chico, T.J.A. orcid.org/0000-0002-7458-5481 (2013) Zebrafish-based small molecule screens for novel cardiovascular drugs. Drug Discovery Today: Technologies, 10 (1). e109-e114. ISSN 1740-6749
Abstract
The zebrafish is increasingly being adopted as an in vivo model of high throughput drug screening. In this brief review we outline the advantages and disadvantages of this approach and summarize recent screens that have attempted to identify novel small molecules with activity on the cardiovascular system.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2012 Elsevier Ltd. This is an author produced version of a paper subsequently published in Drug Discovery Today: Technologies. Uploaded in accordance with the publisher's self-archiving policy. Article available under the terms of the CC-BY-NC-ND licence (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
Keywords: | Animals; Cardiovascular Agents; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Zebrafish |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Professional Services (Sheffield) The University of Sheffield > Sheffield Teaching Hospitals |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 18 Jun 2018 14:10 |
Last Modified: | 21 Jun 2018 04:18 |
Published Version: | https://doi.org/10.1016/j.ddtec.2012.01.005 |
Status: | Published |
Publisher: | Elsevier |
Refereed: | Yes |
Identification Number: | 10.1016/j.ddtec.2012.01.005 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:131323 |
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