Crampin, E.J., Smith, N.P., Langham, A.E., Clayton, R.H. and Orchard, C.H. (2006) Acidosis in models of cardiac ventricular myocytes. Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 364 (1842). pp. 1171-1186. ISSN 1471-2962
The effects of acidosis on cardiac electrophysiology and excitation–contraction coupling have been studied extensively. Acidosis decreases the strength of contraction and leads to altered calcium transients as a net result of complex interactions between protons and a variety of intracellular processes. The relative contributions of each of the changes under acidosis are difficult to establish experimentally, however, and significant uncertainties remain about the key mechanisms of impaired cardiac function.
In this paper, we review the experimental findings concerning the effects of acidosis on the action potential and calcium handling in the cardiac ventricular myocyte, and we present a modelling study that establishes the contribution of the different effects to altered Ca2+ transients during acidosis. These interactions are incorporated into a dynamical model of pH regulation in the myocyte to simulate respiratory acidosis in the heart.
|Copyright, Publisher and Additional Information:||© 2006 The Royal Society|
|Keywords:||cardiac ventricular myocyte, acidosis, pH regulation, intracellular calcium handling, mathematical model|
|Institution:||The University of Leeds, The University of Sheffield|
|Academic Units:||The University of Leeds > Faculty of Maths and Physical Sciences (Leeds) > School of Chemistry (Leeds)
The University of Sheffield > Faculty of Engineering (Sheffield) > Department of Computer Science (Sheffield)
|Depositing User:||Repository Officer|
|Date Deposited:||19 Jun 2006|
|Last Modified:||06 Jun 2014 05:52|
|Publisher:||The Royal Society|