Background: Helping people living with HIV (PLWH) to maintain long‐term health as they age is central to HIV care and involves monitoring for chronic HIV‐associated co‐morbidities. Chronic lung disease (CLD) is recognised to be more common in PLWH as they age, but UK data on CLD prevalence and phenotype in PLWH are limited, particularly in female, non‐white, never smoking groups, and studies of progression over time are lacking.
This pilot study aimed to obtain preliminary data on CLD in these subgroups and establish a simple scheme for monitoring lung health of PLWH for a future longitudinal study.
Methods: Cross‐sectional pilot of CLD prevalence among PLWH on ART by age, gender, ethnicity and smoking status using convenience sampling of PLWH attending routine clinics. PLWH completed a web‐based questionnaire of self‐reported chronic cough, wheeze & phlegm production using the BOLD study questions; dyspnoea using the Medical Research Council (mMRC) scale; health related quality of life (EQ‐5D‐5L); respiratory, smoking and other lung exposure history. Forced Expiratory Volume (FEV)1 and Forced Vital Capacity (FVC) were measured by spirometry and z‐scores derived from Global Lung Initiative age, sex and ethnicity predicted values. We extracted HIV data from clinical records and evaluated the suitability and acceptability of the measurements. 50 HIV negative controls matched for smoking status were also assessed.
Results: We recruited 150 PLWH, median age 46, 31% female, 47% white. 65% were never smokers, 45% reported childhood exposure to solid cooking fuel. 49% reported a history of PCP, TB or pneumonia and 26% a diagnosis of COPD, asthma or bronchiectasis. All groups had lung ill‐health (table) that correlated with EQ5D5L.
Conclusion: CLD may affect all PLWH subgroups. These data and methods can inform a longitudinal study of CLD in UK PLWH.
CORE (COnnecting REpositories)
CORE (COnnecting REpositories)