Adaptive designs in clinical trials: why use them, and how to run and report them

Pallmann, P., Bedding, A.W., Choodari-Oskooei, B. et al. (13 more authors) (2018) Adaptive designs in clinical trials: why use them, and how to run and report them. BMC Medicine, 16 (29). ISSN 1741-7015

Abstract

Metadata

Authors/Creators:
  • Pallmann, P.
  • Bedding, A.W.
  • Choodari-Oskooei, B.
  • Flight, L. https://orcid.org/0000-0002-9569-8290
  • Dimairo, M.
  • Hampson, L.V.
  • Holmes, J.
  • Mander, A.P.
  • Odondi, L.
  • Sydes, M.R.
  • Villar, S.S.
  • Wason, J.M.S.
  • Weir, C.J.
  • Wheeler, G.M.
  • Yap, C.
  • Jaki, T.
Copyright, Publisher and Additional Information: © The Author(s). 2018Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, andreproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to theCreative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver(http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Keywords: Statistical methods; Adaptive design; Flexible design; Interim analysis; Design modification; Seamless design
Dates:
  • Published: 28 February 2018
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Health and Related Research (Sheffield) > Sheffield Centre for Health and Related Research
Funding Information:
FunderGrant number
NATIONAL INSTITUTE FOR HEALTH RESEARCHDRF-2015-08-013
Depositing User: Symplectic Sheffield
Date Deposited: 02 Mar 2018 11:25
Last Modified: 02 Mar 2018 11:25
Published Version: https://doi.org/10.1186/s12916-018-1017-7
Status: Published
Publisher: BioMed Central
Refereed: Yes
Identification Number: https://doi.org/10.1186/s12916-018-1017-7

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