Epigenetic Dysregulation of the Drp1 Binding Partners MiD49 and MiD51 Increases Mitotic Mitochondrial Fission and Promotes Pulmonary Arterial Hypertension: Mechanistic and Therapeutic Implications

Chen, K.-H., Dasgupta, A., Lin, J. et al. (13 more authors) (2018) Epigenetic Dysregulation of the Drp1 Binding Partners MiD49 and MiD51 Increases Mitotic Mitochondrial Fission and Promotes Pulmonary Arterial Hypertension: Mechanistic and Therapeutic Implications. Circulation, 117. 031258. ISSN 0009-7322

Abstract

Metadata

Authors/Creators:
  • Chen, K.-H.
  • Dasgupta, A.
  • Lin, J.
  • Potus, F.
  • Bonnet, S.
  • Iremonger, J.
  • Fu, J.
  • Mewburn, J.
  • Wu, D.
  • Dunham-Snary, K.
  • Theilmann, A.L.
  • Jing, Z.-C.
  • Hindmarch, C.
  • Ormiston, M.L.
  • Lawrie, A. https://orcid.org/0000-0003-4192-9505
  • Archer, S.L.
Copyright, Publisher and Additional Information: © 2018 American Heart Association. This is an author produced version of a paper subsequently published in Circulation. Uploaded in accordance with the publisher's self-archiving policy.
Keywords: cell cycle; cyclin dependent kinase (CDK); dynamin related protein 1 (Drp1); extracellular signal regulated kinase (ERK); miR-34a-3p; mitochondrial dynamics; mitochondrial fission
Dates:
  • Published: 5 February 2018
  • Accepted: 22 January 2018
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > Department of Cardiovascular Science (Sheffield)
The University of Sheffield > Sheffield Teaching Hospitals
Funding Information:
FunderGrant number
BRITISH HEART FOUNDATIONFS/13/48/30453
BRITISH HEART FOUNDATIONPG/11/116/29288
Depositing User: Symplectic Sheffield
Date Deposited: 28 Feb 2018 09:58
Last Modified: 05 Aug 2018 00:38
Published Version: https://doi.org/10.1161/CIRCULATIONAHA.117.031258
Status: Published online
Publisher: American Heart Association
Refereed: Yes
Identification Number: https://doi.org/10.1161/CIRCULATIONAHA.117.031258
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