SRSF1-dependent nuclear export of C9ORF72 repeat-transcripts: targeting toxic gain-of-functions induced by protein sequestration as a selective therapeutic strategy for neuroprotection

Castelli, L.M., Lin, Y.H., Ferraiuolo, L. et al. (6 more authors) (2018) SRSF1-dependent nuclear export of C9ORF72 repeat-transcripts: targeting toxic gain-of-functions induced by protein sequestration as a selective therapeutic strategy for neuroprotection. Therapeutic Targets for Neurological Diseases, 4. e1619. ISSN 2376-0478

Abstract

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Authors/Creators:
Copyright, Publisher and Additional Information: © 2017 The Authors. Licensed under a Creative Commons Attribution 4.0 International License which allows users including authors of articles to copy and redistribute the material in any medium or format, in addition to remix, transform, and build upon the material for any purpose, even commercially, as long as the author and original source are properly cited or credited.
Keywords: Amyotrophic lateral sclerosis; Frontotemporal dementia; Neurodegeneration; Microsatellite repeat expansions; C9ORF72; RNA nuclear export; SRSF1; NXF1; RAN translation; Therapeutic strategy
Dates:
  • Published: 15 January 2018
  • Accepted: 15 January 2018
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > Department of Neuroscience (Sheffield)
The University of Sheffield > Sheffield Teaching Hospitals
Funding Information:
FunderGrant number
EUROPEAN RESEARCH COUNCILGTNCTV - 294745
EUROPEAN RESEARCH COUNCILDYNAMITO - 309742
MEDICAL RESEARCH COUNCILMR/M010864/1
MOTOR NEURONE DISEASE ASSOCIATIONMND005891
THIERRY LATRAN FOUNDATIONFTL AAP 2016
Depositing User: Symplectic Sheffield
Date Deposited: 19 Jan 2018 15:32
Last Modified: 19 Jan 2018 15:39
Published Version: https://doi.org/10.14800/ttnd.1619
Status: Published
Publisher: Smart Science and Technology
Refereed: Yes
Identification Number: https://doi.org/10.14800/ttnd.1619

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