Metherell, A.J., Cullen, W., Williams, N.H. et al. (1 more author) (2018) Binding of hydrophobic guests in a coordination cage cavity is driven by liberation of 'high-energy' water. Chemistry - A European Journal, 24 (7). pp. 1554-1560. ISSN 0947-6539
Abstract
The cavity of an M8L12 cubic coordination cage can accommodate a cluster of ten water molecules in which the average number of hydrogen bonds per water molecule is 0.5 H-bonds less than it would be in the bulk solution. The presence of these 'hydrogen-bond frustrated' or 'high-energy' water molecules in the cavity results in the hydrophobic effect associated with guest binding being predominantly enthalpy-based, as these water molecules can improve their hydrogen-bonding environment on release. This contrasts with the classical form of the hydrophobic effect in which the favourable entropy change associated with release of ordered molecules from hydrophobic surfaces dominates. For several guests Van't Hoff plots showed that the free energy of binding in water is primarily enthalpy-driven. For five homologous pairs of guests related by the presence or absence of a CH2 group, the incremental changes to ∆H and T∆S for guest binding ¬- i.e. ∆∆H and T∆∆S, the difference in contributions arising from the CH2 group - are consistently 5±1 kJ mol-1 for ∆∆H and 0±1 kJ mol-1 for T∆∆S. This systematic dominance of ∆H in the binding of hydrophobic guests is consistent with the view that guest binding is dominated by release of 'high energy' water molecules into a more favourable solvation environment, as has been demonstrated recently for some members of the cucurbituril family.
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Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2017 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
Keywords: | coordination cage; host-guest chemistry; hydrophobic effect; molecular recognition; supramolecular chemistry |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Science (Sheffield) > Department of Chemistry (Sheffield) |
Funding Information: | Funder Grant number ENGINEERING AND PHYSICAL SCIENCE RESEARCH COUNCIL (EPSRC) EP/N031555/1 |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 08 Dec 2017 14:22 |
Last Modified: | 09 Apr 2024 15:49 |
Status: | Published |
Publisher: | Wiley |
Refereed: | Yes |
Identification Number: | 10.1002/chem.201704163 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:124775 |
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