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Patients' preferences for the management of non-metastatic prostate cancer: discrete choice experiment

Sculpher, M. (orcid.org/0000-0003-3746-9913), Fry, P., de Winter, P., Payne, H., Emberton, M. and Bryan, S. (2004) Patients' preferences for the management of non-metastatic prostate cancer: discrete choice experiment. British medical journal. 382-384A. ISSN 0959-535X

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Objective To establish which attributes of conservative treatments for prostate cancer are most important to men. Design Discrete choice experiment. Setting Two London hospitals. Participants 129 men with non-metastatic prostate cancer, mean age 70 years; 69 of 118 (58%) with T stage 1 or 2 cancer at diagnosis. Main outcome measures Men's preferences for, and trade-offs between, the attributes of diarrhoea, hot flushes, ability to maintain an erection, breast swelling or tenderness, physical energy, sex drive, life expectancy, and out of pocket expenses. Results The men's responses to changes in attributes were all statistically significant. When asked to assume a starting life expectancy of five years, the men were willing to make trade-offs between life expectancy and side effects. On average, they were most willing to give up life expectancy to avoid limitations in physical energy (mean three months) and least willing to trade life expectancy to avoid hot flushes (mean 0.6 months to move from a moderate to mild level or from mild to none). Conclusions Men with prostate cancer are willing to participate in a relatively complex exercise that weighs up the advantages and disadvantages of various conservative treatments for their condition. They were willing to trade off some life expectancy to be relieved of the burden of troublesome side effects such as limitations in physical energy.

Item Type: Article
Copyright, Publisher and Additional Information: © 2004 BMJ Publishing Group Ltd
Institution: The University of York
Academic Units: The University of York > Centre for Health Economics (York)
The University of York > Social Policy and Social Work (York)
Depositing User: Repository Officer
Date Deposited: 24 Sep 2004
Last Modified: 03 May 2016 18:32
Published Version: http://dx.doi.org/10.1136/bmj.37872.497234.44
Status: Published
Refereed: Yes
URI: http://eprints.whiterose.ac.uk/id/eprint/122

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